Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation

In this study, we have designed, synthesized and full characterized a novel biological based acidic nano organocatalyst via condensations reaction of uric acid phosphorous acid. The obtained compound was named theacrine tetrakis(phosphonic acid) (TTPA) prepared under refluxing ethanol. This new applied as an efficient recyclable catalyst for the preparation pyridines with indole moieties cooperative vinylogous anomeric oxidation good to excellent yields.